Masafumi Yano Selected Research

Dantrolene (Dantrium)

1/2023	RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure.
1/2023	RyR2-stabilization therapy with dantrolene against left ventricular remodeling and lethal arrhythmia in heart failure.
1/2023	Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice.
10/2022	Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis.
10/2022	Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice.
1/2022	Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.
9/2020	Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress.
1/2020	Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice.
1/2020	A multicenter, randomized, double-blind, controlled study to evaluate the efficacy and safety of dantrolene on ventricular arrhythmia as well as mortality and morbidity in patients with chronic heart failure (SHO-IN trial): rationale and design.
1/2020	Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts.

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Masafumi Yano Research Topics

Disease

49	Heart Failure 07/2023 - 03/2002
20	Cardiac Arrhythmias (Arrythmia) 01/2023 - 09/2005
12	Ventricular Tachycardia 01/2023 - 06/2005
11	Atrial Fibrillation 08/2023 - 01/2002
10	Polymorphic catecholergic ventricular tachycardia 01/2019 - 09/2005
6	Tachycardia (Tachyarrhythmias) 08/2023 - 03/2003
5	Hypertrophy 01/2023 - 12/2006
5	Malignant Hyperthermia 10/2022 - 05/2009
4	Ventricular Remodeling 01/2023 - 03/2002
4	Sarcoidosis (Schaumann Disease) 11/2019 - 01/2015
3	Cardiomegaly (Heart Hypertrophy) 07/2023 - 12/2018
3	Systolic Heart Failure 10/2022 - 01/2012
3	Cardiotoxicity 09/2022 - 03/2007
3	Heart Diseases (Heart Disease) 09/2022 - 12/2006
2	Hypertriglyceridemia 10/2023 - 01/2021
2	Hypertension (High Blood Pressure) 07/2023 - 10/2021
2	Left Ventricular Dysfunction 07/2023 - 03/2007
2	Hemorrhage 05/2023 - 01/2021
2	Stroke (Strokes) 05/2023 - 01/2021
2	Infarction (Infarctions) 01/2023 - 04/2002
2	Cardiovascular Diseases (Cardiovascular Disease) 09/2022 - 01/2012
2	Neoplasms (Cancer) 09/2022 - 07/2019
2	Dyspnea (Shortness of Breath) 09/2022 - 01/2019
2	Pathologic Constriction (Stenosis) 03/2022 - 06/2017
2	Vasculitis (Vasculitides) 01/2022 - 01/2021
2	Fibrosis (Cirrhosis) 01/2021 - 03/2008
2	Ventricular Fibrillation 01/2020 - 10/2013
2	Myositis (Idiopathic Inflammatory Myopathies) 07/2019 - 01/2018
2	Idiopathic Pulmonary Fibrosis 01/2019 - 01/2016
2	Lupus Nephritis 07/2018 - 01/2017
2	Aortic Valve Insufficiency (Aortic Regurgitation) 01/2018 - 01/2018
2	Cardiomyopathies (Cardiomyopathy) 01/2018 - 06/2006
2	Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy) 01/2006 - 09/2005
1	Type 2 Diabetes Mellitus (MODY) 10/2023
1	Chronic Obstructive Pulmonary Disease (COPD) 04/2023
1	Myocardial Infarction 01/2023
1	Experimental Arthritis 10/2022
1	Arthritis (Polyarthritis) 10/2022
1	Vascular System Injuries 10/2022
1	Leukemia 09/2022
1	Coronary Stenosis (Coronary Artery Stenosis) 03/2022
1	Pulmonary Hypertension 01/2022
1	Churg-Strauss Syndrome (Allergic Angiitis) 01/2022
1	Bundle-Branch Block (Fascicular Block) 12/2021
1	Atrioventricular Block 12/2021
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2021

Drug/Important Bio-Agent (IBA)

39	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2023 - 03/2002
13	Dantrolene (Dantrium)FDA LinkGeneric 01/2023 - 05/2009
12	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2023 - 04/2010
7	Proteins (Proteins, Gene)FDA Link 07/2022 - 03/2005
6	Biomarkers (Surrogate Marker)IBA 04/2023 - 01/2011
5	8-Hydroxy-2'-DeoxyguanosineIBA 12/2017 - 01/2011
4	omega-Chloroacetophenone (Mace)IBA 08/2023 - 03/2022
4	Epinephrine (Adrenaline)FDA LinkGeneric 01/2020 - 11/2010
3	CatecholaminesIBA 01/2022 - 10/2013
3	Amino Acids FDA Link 01/2020 - 11/2010
3	Milrinone (Primacor)FDA LinkGeneric 01/2019 - 01/2012
3	SteroidsIBA 07/2018 - 06/2016
3	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 06/2006 - 03/2002
3	tacrolimus binding protein 1BIBA 03/2003 - 03/2002
2	HomocysteineIBA 01/2023 - 07/2022
2	UbiquitinIBA 01/2023 - 07/2022
2	Immunoglobulin G (IgG)IBA 10/2022 - 01/2015
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 01/2017
2	Triglycerides (Triacylglycerol)IBA 01/2021 - 01/2015
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2020 - 01/2016
2	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2020 - 01/2018
2	EnzymesIBA 07/2019 - 01/2018
2	landiololIBA 01/2019 - 01/2014
2	Mycophenolic Acid (Cellcept)FDA LinkGeneric 07/2018 - 01/2017
2	AntibodiesIBA 03/2018 - 01/2015
2	Mineralocorticoid Receptor AntagonistsIBA 12/2017 - 02/2005
2	C-Reactive ProteinIBA 01/2015 - 01/2011
2	olmesartanIBA 05/2014 - 10/2011
2	CalciumIBA 12/2012 - 01/2003
2	Carvedilol (Coreg)FDA LinkGeneric 01/2012 - 04/2007
2	Angiotensin Receptors (Angiotensin II Receptor)IBA 10/2011 - 02/2004
2	Protein Phosphatase 1IBA 01/2011 - 06/2006
2	Peptides (Polypeptides)IBA 09/2005 - 06/2005
2	K201 compoundIBA 03/2003 - 01/2003
1	(R)-2-(3-((benzoxazol-2-yl-d4 (3- (4- methoxyphenoxy- d7)propyl)amino)methyl)phenoxy) butanoic acidIBA 10/2023
1	MineralocorticoidsIBA 07/2023
1	SaltsIBA 07/2023
1	Platelet-Derived Growth FactorIBA 10/2022
1	cabozantinibIBA 09/2022
1	Small Interfering RNA (siRNA)IBA 07/2022
1	Angiotensin IIIBA 07/2022
1	Green Fluorescent ProteinsIBA 07/2022
1	MonocrotalineIBA 01/2022
1	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2022
1	macitentanIBA 10/2021
1	lenvatinibIBA 10/2021

Therapy/Procedure

21	Therapeutics 01/2023 - 04/2002
6	Catheter Ablation 08/2023 - 12/2016
4	Transcatheter Aortic Valve Replacement 12/2021 - 02/2016
3	Stents 01/2021 - 04/2016
2	Percutaneous Coronary Intervention 03/2022 - 01/2021
2	Catheters 01/2016 - 11/2015
1	Drug Therapy (Chemotherapy) 07/2023
1	Oral Administration 10/2022